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Royal Berkshire NHS Foundation Trust
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Berkshire West Clinical Commissioning Group
 
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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
Notes:
This formulary is used by multiple organisations. There may be some instances where an item is on the formulary for one organisation but not the others. To help distinguish between each organisation, text will be colour coded, i.e. information relating to the Royal Berkshire NHS Foundation Trust will be in blue and Berkshire Healthcare NHS Foundation Trust will be in purple. Please ensure you read all information detailed under a drug.   
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 Details...
08.01.03  Expand sub section  Antimetabolites
Cytotoxic Drug Azacitidine (Vidaza®)
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Formulary
Red
High Cost Medicine
Royal Berkshire NHS Foundation Trust >> Formulary Item injection

Restricted Item  ONLY in line with NICE TA - link below


note  Commissioning requirements for funding may apply. Please contact pharmacy for details prior to prescribing this item.  
Link  NICE 399 - Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blasts
Link  NICE TA218: azacitidine for myelodysplastic syndromes
   
Cytotoxic Drug Capecitabine (Xeloda®)
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Formulary
Red
Royal Berkshire NHS Foundation Trust >> Formulary Item tablets
Restricted Item ONLY in line with NICE TA - link below

 
Link  NICE TA 100 - Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes’ C) colon cancer
Link  NICE TA 191 - Capecitabine for the treatment of advanced gastric cancer
Link  NICE TA 60 - Guidance on the use of capecitabine and tegafur with uracil for metastatic colorectal cancer
   
Cytotoxic Drug Cladribine
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Formulary
Red
Royal Berkshire NHS Foundation Trust >> Formulary Item injection / infusion
 
   
Cladribine (MAVENCLAD ®)
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Formulary
Red
High Cost Medicine
NHS England

note NHS England Commissioning requirements for funding apply; approval may be required prior to use. Please contact pharmacy for details prior to prescribing this item.

Royal Berkshire NHS Foundation Trust >> Formulary Item >> tablet
Restricted Item ONLY in line with NICE TA - link below

 
Link  NICE TA493: Cladribine tablets for treating relapsing–remitting multiple sclerosis
   
Cytotoxic Drug Cytarabine
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Formulary
Red
Royal Berkshire NHS Foundation Trust >> Formulary Item infusion / injection  
   
Cytotoxic Drug Fludarabine Phosphate (Fludara®)
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Formulary
Red
Royal Berkshire NHS Foundation Trust >> Formulary Item tablets / infusion
Restricted Item ONLY in line with NICE TA - link below
 
Link  NICE TA 119 - Fludarabine monotherapy for the first-line treatment of chronic lymphocytic leukaemia
Link  NICE TA 29 - Guidance on the use of fludarabine for B-cell chronic lymphocytic leukaemia
   
Cytotoxic Drug Fluorouracil
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Formulary
Red
Royal Berkshire NHS Foundation Trust >> Formulary Item infusion

Restricted Item ONLY in line with NICE TA - link below
 
   
Cytotoxic Drug Gemcitabine
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Formulary
Red
Royal Berkshire NHS Foundation Trust >> Formulary Item injection / infusion
Restricted Item ONLY in line with NICE TA - link below
 
Link  NICE TA 116 - Gemcitabine for the treatment of metastatic breast cancer
Link  NICE TA 25 - Guidance on the use of gemcitabine for the treatment of pancreatic cancer
Link  NICE TA 389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
Link  NICE TA 476: Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
   
Cytotoxic Drug Liposomal Cytarabine–Daunorubicin  (Vyxeos®)
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Formulary
Red
High Cost Medicine
NHS England

note NHS England Commissioning requirements for funding apply; approval may be required prior to use. Please contact pharmacy for details prior to prescribing this item.

Royal Berkshire NHS Foundation Trust >> Formulary Item  >> powder for concentrate for solution for infusion
Restricted Item ONLY in line with NICE TA - link below 

 
Link  NICE TA 552: Liposomal cytarabine–daunorubicin for untreated acute myeloid leukaemia
   
Cytotoxic Drug Mercaptopurine
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Formulary
Red
Amber for Gastroenterology Use - click here

Royal Berkshire NHS Foundation Trust >> Formulary Item tablets / oral solution
 
   
Cytotoxic Drug Methotrexate
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Formulary
Amber Prescribing Guidelines

Royal Berkshire NHS Foundation Trust >> Formulary Item tablets / oral solution / injection / Intrathecal injection / infusion

 
Link  APC PG 023 - Methotrexate for the treatment of vasculitis
Link  UKMI QA: alcohol and methotrexate guidance
   
Cytotoxic Drug Pemetrexed (Alimta®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
note NHS England Commissioning requirements for funding apply; approval may be required prior to use. Please contact pharmacy for details prior to prescribing this item.

Royal Berkshire NHS Foundation Trust >> Formulary Item infusion / injection
Restricted Item ONLY in line with NICE TA - link below

 
Link  NICE TA 124 - Pemetrexed for the treatment of non-small-cell lung cancer
Link  NICE TA 135 - Pemetrexed for the treatment of malignant pleural mesothelioma
Link  NICE TA 181 - Pemetrexed for the first-line treatment of non-small-cell lung cancer
Link  NICE TA 190 - Pemetrexed for the maintenance treatment of non-small-cell lung cancer
Link  NICE TA 402 - Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin
   
Raltitrexed (Tomudex®)
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Formulary
Red
Royal Berkshire NHS Foundation Trust >> Formulary Item injection / infusion
 
   
Cytotoxic Drug Tioguanine (Lanvis®)
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Formulary
Red
Royal Berkshire NHS Foundation Trust >> Formulary Item tablets
 
   
Trifluridine & Tipiracil  (Lonsurf®)
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Restricted Drug Restricted
Red
Royal Berkshire NHS Foundation Trust >> Formulary Item tablet

Restricted Item  ONLY in line with NICE TA (link below)

 
Link  NICE TA 405 - Trifluridine–tipiracil for previously treated metastatic colorectal cancer
   
 ....
 Non Formulary Items
Cladribine  (Litak®)

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Non Formulary
Red
Royal Berkshire NHS Foundation Trust>> NON - Formulary Item see generic drug for details (brand may not be available - contact pharmacy for advise)
 
Cytotoxic Drug  Clofarabine  (Evoltra®)

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Non Formulary
Red
Royal Berkshire NHS Foundation Trust>> NON - Formulary Item - contact pharmacy for advice
 
Cytarabine  (DepoCyte®)

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Non Formulary
Red
Royal Berkshire NHS Foundation Trust>> NON - Formulary Item see generic drug for details (brand may not be available - contact pharmacy for advise)
 
Cytotoxic Drug  Tegafur with Uracil  (Uftoral®)

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Non Formulary
Red
Royal Berkshire NHS Foundation Trust>> NON - Formulary Item - contact pharmacy for advice
Link  NICE TA61: Capcitabine and tegafur - Colorectal cancer
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Medicines which should be prescribed by specialists only  

Brown

Drugs that have been reviewed and not recommended for prescribing. These drugs are not considered a cost-effective use of scarce NHS resources. There may be individual patient-specific or clinical reasons why a drug deemed low priority may be suitable for a particular patient. This is for the GP to consider, weighing up the reasons against his/her allocated CCG budget. Where the decision is made to prescribe a low priority drug, detailed documentation must be included in the patients' notes for audit purposes. *Please note that low priority drug requests are unsuitable for the Case Review Committee and therefore should not be sent to this committee. Where new drugs come to market, under APC policy 085, they will be classified Brown until a review is deemed necessary.  

Amber Prescribing Guidelines

Medicines that should be initiated or recommended by a specialist for continuation in primary care. The specialist must notify the primary care provider that the prescribing responsibility has been transferred. Prescribing Guidelines are in place and must be adhered to.  

Amber without Prescribing Guidelines

Medicines that should be initiated or recommended by a specialist for continuation in primary care. The specialist must notify the primary care provider that the prescribing responsibility has been transferred. Prescribing Guidelines are not required for these items.  

Green

Medicines suitable for routine use and can be prescribed within primary care within their licensed indication in accordance with the BNF or other recognised national formulary. Primary care prescribers take full responsibility for prescribing  

Amber

Not Used   

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